Chongqing Huapont Shengchem Phamaceutical Co., Ltd.

EP

20200702-211-J-456

(5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol monohydrate

Vitamin D₃ receptors are widely distributed in the body, and among them, they exist in keratinocytes in the skin. The bright red papules in psoriasis result from abnormal growth and production of keratinocytes. Calcipotriol is a synthetic vitamin D₃ analogue that regulates the production and proliferation of skin cells.

147657-22-5

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Shandong Xiuhua Pharmaceutical Co. Ltd

USP

20180528-209-J-22

N/A

N/A

Calcium polycarbophil is a stool stabilizer. Based on its chemical structure, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol presenting a calcium atom as a counter-ion. Polycarbophil is used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea.

9003-97-8

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IPCA

EP

20180406-209-J-47(1)

1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline

1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline

2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide

2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide

3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine

3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine

Chlorphthalidolone

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of chlorthalidone's anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume, decreased cardiac output and therefore overall reduction in blood pressure.

Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce the risk of stroke, myocardial infarction, heart failure, and cardiovascular all-cause mortality in patients with hypertension. In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and heart failure when compared to Lisinopril, Amlodipine, or Doxazosin. Further studies have indicated that low-dose thiazides are as good as, and in some secondary endpoints, better than β-blockers, ACE inhibitors, Calcium Channel Blockers or ARBs.

Chlorthalidone has been shown to have a number of pleiotropic effects that differentiate it from other diuretics such as Hydrochlorothiazide. In addition to its antihypertensive effects, chlorthalidone has also been shown to decrease platelet aggregation and vascular permeability, as well as promote angiogenesis in vitro, which is thought to be partly the result of reductions in carbonic anhydrase–dependent pathways. These pathways may play a role in chlorthalidone's cardiovascular risk reduction effects

77-36-1

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Alembic Pharmaceuticals Limited(API Unit-1)

In-house

20180814-209-J-48(3)

N/A

Fenofibric acid choline salt

Fenofibrate is a third generation fibric acid derivative that is predominantly administered as monotherapy to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B and alternatively to increase high-density lipoprotein cholesterol in patients diagnosed with primary hyperlipidemia or mixed dyslipidemia and to reduce triglycerides in patients with severe hypertriglyceridemia. Fenofibrate however is generally extremely lipophilic, largely insoluble in water, and poorly absorbed ¹. As the primary active metabolite of fenofibrate however, various hydrophilic salt formulations of fenofibric acid have since been developed, resulting in therapeutic agents that demonstrate far greater solubility, absorption throughout the gastrointestinal tract, bioavailability, and capability to be administered irrespective of patient food intake

856676-23-8

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Yantai Dongcheng Biochemicals Co., Ltd.

KP

20130122-173-I-229-01(11)

N/A

Chondroitin sulfates

Chondroitin 4-sulfate disodium salt

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific patterns. Depending on the predominating disaccharide unit, it will present different biological activities. Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.

24967-93-9

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Shanghai Pharma Group Changzhou Kony Pharmaceutical Co.,Ltd.

USP

20190111-209-J-300

6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.

29342-05-0

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Shanghai Pharma Group Changzhou Kony Pharmaceutical Co.,Ltd.

USP

20180921-209-J-46

6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.

41621-49-2

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Union quimico farmaceutica, S.A

USP

20060302-27-B-229-04(3)

(Z)-N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine

1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine

2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

51481-61-9

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Symbiotica Speciality Ingredients Sdn. Bhd

USP

20170516-93-E-131-08

21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate

Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974.

Clobetasol Propionate was granted FDA approval on 27 December 1985.

25122-46-7

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