Zhejiang East-Asia Phamaceutical Co.,Ltd

USP

20190111-167-I-565-06

N/A 

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.^Label It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.^5,11 Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981.⁹ At this time it was considered a significant improvement over previous antifungals, miconazole and clotrimazole, due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.^9,10 These effects combined with waning efficacy led to its eventual replacement by triazole agents, fluconazole, itraconazole, [voraconazole], and posaconazole. Ketoconazole and its predecessor clotrimazole continue to be used in topical formulations.

65277-42-1

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Saurav Chemicals Limited

USP

20170926-61-C-362-12

rac-Ketorolac

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

74103-07-4

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